Article
Expression of BCL-2 in primary breast cancer and its correlation with tumour phenotype. For the International (Ludwig) Breast Cancer Study Group.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 May 1994
Nathan B, Gusterson B, Jadayel D, O'Hare M, Anbazhagan R, Jayatilake H, Ebbs S, Micklem K, Price K, Gelber R
Abstract excerpt
BACKGROUND: The role of apoptosis (programmed cell death) in the development and progression of breast cancer is unknown. Recently the bcl-2 gene has been shown to block apoptosis and thus may promote tumour development. BCL-2 is localized to the luminal cells of the normal breast, which are considered to be the origin of malignant breast disease. PATIENTS AND METHODS: Immunocytochemistry using anti bcl-2-...
Topics
- Adult
- Aged
- Aged, 80 and over
- Apoptosis
- Blotting, Southern
- Blotting, Western
- Breast Neoplasms
- ErbB Receptors
- Female
- Gene Expression