Article
Paradoxical inhibition of solid tumor cell growth by bcl2.
Cancer research - 15 Jul 1994
Pietenpol J A, Papadopoulos N, Markowitz S, Willson J K, Kinzler K W, Vogelstein B
Abstract excerpt
The BCL2 gene product has been demonstrated to prevent apoptosis and provide a selective growth advantage to many cell types. We report an unexpected effect of bcl2 expression on the in vitro growth of several solid tumor cell lines. Expression of bcl2 in these cell lines resulted in growth inhibition similar to that seen with p53. In contrast, a COOH-terminal deletion mutant of bcl2 was unable to suppress...
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