Paradoxical inhibition of solid tumor cell growth by bcl2.

Article

Paradoxical inhibition of solid tumor cell growth by bcl2.

Cancer research - 15 Jul 1994

Pietenpol J A, Papadopoulos N, Markowitz S, Willson J K, Kinzler K W, Vogelstein B

Abstract excerpt

The BCL2 gene product has been demonstrated to prevent apoptosis and provide a selective growth advantage to many cell types. We report an unexpected effect of bcl2 expression on the in vitro growth of several solid tumor cell lines. Expression of bcl2 in these cell lines resulted in growth inhib...

Topics

Base Sequence
Cell Division
Humans
Molecular Sequence Data
Mutation
Neoplasms
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-bcl-2
Proto-Oncogenes
Tumor Cells, Cultured

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