Article
Regulators of apoptosis in human breast cancer.
Clinical biochemistry - 1 Jul 1999
Eissa S, Labib R, Khalifa A, Swelam N, Khalil F, El-Shenawy A M
Abstract excerpt
OBJECTIVES: Apoptosis or programmed cell death represents a mechanism by which tumor cells with DNA damage can be deleted. Bcl-2 and p53 gene products have been both linked to apoptosis. Bcl-2 plays a role as an inhibitor of apoptosis that may extend the viability of cells containing genetic alterations and facilitate tumor progression. Mutant p53 has a similar effect. The purpose of this study was to investigate...
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