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Article

High association of T1858-G1896 precore mutations with impaired base pairing and high hepatitis B virus DNA levels in HBeAg-negative chronically infected patients.

Archives of virology - 1 Jul 2017

Castelain Sandrine, Descamps Véronique, Brochot Etienne, Helle François, Duverlie Gilles, Nguyen-Khac Eric, François Catherine

Abstract excerpt

The progression of liver disease in hepatitis B virus (HBV) infection is fostered by active virus replication. Mutations in the basal core promoter (BCP) and precore (PC) regions of the HBV genome are known to have an impact on viral replication. The aim of the present study was to assess the correlation of mutation profiles in the BCP and PC regions with the viral load in HBeAg-negative chronically infected...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28289975
DOI: 10.1007/s00705-017-3312-6

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