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Article

Hepatitis B virus genotype A rarely circulates as an HBe-minus mutant: possible contribution of a single nucleotide in the precore region.

Journal of virology - 1 Sept 1993

Li J S, Tong S P, Wen Y M, Vitvitski L, Zhang Q, Trépo C

Abstract excerpt

The emergence of HBe-minus hepatitis B virus (HBV) mutants, usually through a UAG nonsense mutation at codon 28 of the precore region, helps the virus to survive the anti-HBe immune response of the host. Host and viral factors that predispose to the emergence of such mutants are not well characterized. The fact that the precore region forms a hairpin structure essential for the packaging of viral pregenomic RNA...

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Identifiers

PMID: 8350403
DOI: 10.1128/JVI.67.9.5402-5410.1993
PMCID: PMC237941

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