Article
Insertion/deletion polymorphism of the angiotensin-converting enzyme gene is strongly associated with coronary heart disease in non-insulin-dependent diabetes mellitus.
Proceedings of the National Academy of Sciences of the United States of America - 26 Apr 1994
Ruiz J, Blanché H, Cohen N, Velho G, Cambien F, Cohen D, Passa P, Froguel P
Abstract excerpt
Non-insulin-dependent diabetes mellitus (NIDDM) is considered a model of premature atherosclerosis with a strong genetic component. We have investigated the role of angiotensin-converting enzyme (ACE; EC 3.4.15.1) gene in 316 unrelated NIDDM individuals, 132 who had myocardial infarction or signi...
Topics
- Alleles
- Coronary Disease
- Diabetes Mellitus, Type 2
- Female
- Gene Deletion
- Gene Frequency
- Humans
- Male
- Middle Aged
- Peptidyl-Dipeptidase A
- Regression Analysis
- Risk Factors