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Article

Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction.

Nature - 15 Oct 1992

Cambien F, Poirier O, Lecerf L, Evans A, Cambou J P, Arveiler D, Luc G, Bard J M, Bara L, Ricard S

Abstract excerpt

Factors involved in the pathogenesis of atherosclerosis, thrombosis and vasoconstriction contribute to the development of coronary heart disease. In a study comparing patients after myocardial infarction with controls, we have explored a possible association between coronary heart disease and a variation found in the gene encoding angiotensin-converting enzyme (ACE). The polymorphism ACE/ID is strongly associated...

Topics

Adult
Europe
Genetic Variation
Genotype
Humans
Male
Middle Aged
Myocardial Infarction
Peptidyl-Dipeptidase A
Polymorphism, Genetic
Risk Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sequence Deletion

Source

Identifiers

PMID: 1328889
DOI: 10.1038/359641a0

Genes

ACE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1328889-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction.PMID 1328889Read ↗

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The angiotensin‐converting enzyme (ACE) genetic polymorphism: its relationship with plasma ACE level and myocardial infarctionSemantic proximity Read ↗

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Angiotensin converting enzyme gene deletion allele is independently and strongly associated with coronary atherosclerosis and myocardial infarction.Semantic proximity Read ↗

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