The D allele of the angiotensin-converting enzyme gene contributes towards blood LDL-cholesterol levels and the presence of hypertension.

doi:10.1016/s0021-9150(99)00075-1

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Article

The D allele of the angiotensin-converting enzyme gene contributes towards blood LDL-cholesterol levels and the presence of hypertension.

Atherosclerosis - 1 Aug 1999

Oren I, Brook J G, Gershoni-Baruch R, Kepten I, Tamir A, Linn S, Wolfovitz E

Abstract excerpt

Coronary artery disease is a polygenic disease whose phenotypic manifestation depends on the interaction of the genetic background with a number of environmental factors. Recently, the gene coding for the angiotensin-converting enzyme (ACE) has been characterized and a deletion/insertion (D/I) polymorphism was defined. The prevalence of the three genotypes and their association with coronary artery disease (CAD)...

Topics

Adult
Aged
Alleles
Blood Pressure
Cholesterol, LDL
Coronary Artery Disease
DNA
DNA Transposable Elements
Gene Deletion
Gene Frequency
Genetic Markers
Genotype
Humans
Hypertension
Male

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Open in PubMed

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PMID: 10488952
DOI: 10.1016/s0021-9150(99)00075-1

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Middle Aged

Peptidyl-Dipeptidase A

Polymerase Chain Reaction