Article
Angiotensin-converting enzyme gene polymorphism is associated with coronary heart disease in non-insulin-dependent diabetic patients evaluated for 9 years.
Metabolism: clinical and experimental - 1 Oct 1998
Huang X H, Rantalaiho V, Wirta O, Pasternack A, Koivula T, Hiltunen T P, Nikkari T, Lehtimäki T
Abstract excerpt
The insertion/deletion (I/D) polymorphism of the human angiotensin-converting enzyme (ACE) gene is a major determinant of circulating ACE levels. Recent studies have found the ACE D allele to be associated with an increased risk for coronary heart disease (CHD) in diabetic and nondiabetic subjects. This association has not been evaluated in prospective studies. We therefore studied the relationship between ACE...
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