Article
Angiotensin-converting enzyme gene polymorphism is associated with coronary heart disease in non-insulin-dependent diabetic patients evaluated for 9 years.
Metabolism: clinical and experimental - 1 Oct 1998
Huang X H, Rantalaiho V, Wirta O, Pasternack A, Koivula T, Hiltunen T P, Nikkari T, Lehtimäki T
Abstract excerpt
The insertion/deletion (I/D) polymorphism of the human angiotensin-converting enzyme (ACE) gene is a major determinant of circulating ACE levels. Recent studies have found the ACE D allele to be associated with an increased risk for coronary heart disease (CHD) in diabetic and nondiabetic subject...
Topics
- Adult
- Aged
- Alleles
- Coronary Disease
- Diabetes Mellitus, Type 2
- Genotype
- Humans
- Middle Aged
- Peptidyl-Dipeptidase A
- Polymorphism, Genetic
- Prospective Studies
- Risk Factors
- Time Factors