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Article

Derivation of androgen‐independent human LNCaP prostatic cancer cell sublines: Role of bone stromal cells

1 May 1994

Abstract excerpt

A model of human prostate cancer was established to study cellular interaction between prostate cancer and bone stroma in vivo. In this model, subcutaneous co-injection of 2 non-tumorigenic human cell lines--LNCaP, a prostate cancer cell line, and MS, a bone stromal cell-line--into intact adult male mice resulted in formation of carcinomas that secreted prostate-specific antigen (PSA), a clinically useful human...

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PMID: 8169003
DOI: 10.1002/ijc.2910570319

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