Culture of mouse prostatic epithelial cells from genetically engineered mice.

Abstract excerpt

BACKGROUND: The lack of appropriate prostate cancer models is a major problem for prostate cancer research. Progress has been made towards the development of better in vivo rodent genetic models for prostatic disease. However, an in vitro model is often preferred for the elucidation of cellular mechanisms involved in the disease. METHODS: We microdissected the four prostatic lobes from young male mice, harvested...

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