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Article

Spontaneous cancer-stromal cell fusion as a mechanism of prostate cancer androgen-independent progression.

PloS one - 1 Jan 2012

Wang Ruoxiang, Sun Xiaojuan, Wang Christopher Y, Hu Peizhen, Chu Chia-Yi, Liu Shurong, Zhau Haiyen E, Chung Leland W K

Abstract excerpt

We have previously shown that human prostate cancer cells are capable of acquiring malignant attributes through interaction with stromal cells in the tumor microenvironment, while the interacting stromal cells can also become affected with both phenotypic and genotypic alterations. This study used a co-culture model to investigate the mechanism underlying the co-evolution of cancer and stromal cells. Red...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22880071
DOI: 10.1371/journal.pone.0042653
PMCID: PMC3411834

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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