Article
Androgen deprivation induces selective outgrowth of aggressive hormone-refractory prostate cancer clones expressing distinct cellular and molecular properties not present in parental androgen-dependent cancer cells.
Cancer journal (Sudbury, Mass.) - 1 Jan 2000
Tso C L, McBride W H, Sun J, Patel B, Tsui K H, Paik S H, Gitlitz B, Caliliw R, van Ophoven A, Wu L, deKernion J, Belldegrun A
Abstract excerpt
PURPOSE: The mechanism of progression of human prostate cancer (CaP) cells under androgen ablation therapy remains unclear. To study the alternative pathways of CaP cell growth under conditions of androgen deprivation, androgen-independent CaP variants were selected and expanded from an androgen-...
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