p53 gene mutants expression, cellular proliferation and differentiation in oesophageal carcinoma and non-cancerous epithelium.

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Article

p53 gene mutants expression, cellular proliferation and differentiation in oesophageal carcinoma and non-cancerous epithelium.

Anticancer research - 1 Jan 2000

Jaskiewicz K, De Groot K M

Abstract excerpt

An immunohistochemical study of 155 squamous cell carcinomas of the oesophagus, squamous epithelium adjacent to the tumour (n = 80), dysplastic epithelium (n = 16) and controls (n = 23) indicates that Ki67 and p53 expression is frequently present in premalignant oesophageal lesions and their related squamous cell carcinomas. Positive expression of both antibodies in apparently normal epithelium can signify early...

Topics

Carcinoma, Squamous Cell
Cell Differentiation
Cell Division
Epidermal Growth Factor
Epithelial Cells
Esophageal Neoplasms
Esophagus
Gene Expression
Genes, p53
Humans
Immunohistochemistry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ki-67 Antigen

Mutation

Neoplasm Proteins

Nuclear Proteins

Transforming Growth Factor alpha

Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 8166440

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8166440-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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