Article
Prevalence and polymorphism of human VH3 genes.
Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 1990
Sasso E H, Van Dijk K W, Milner E C
Abstract excerpt
To better understand heterogeneity of human VH genes, we have studied polymorphism among three homologous genes from VH3, the most complex human VH gene family. Sequence-specific oligonucleotide probes were used to identify the germ-line source of each gene. The fetally expressed gene 56p1, and the germ-line VH element 1.9III, were identified and shown to be distinct. Also identified was T5M10, a VH element that...
Topics
- Alleles
- Base Sequence
- Genes, Immunoglobulin
- Haplotypes
- Humans
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- Molecular Sequence Data
- Oligonucleotide Probes
- Polymorphism, Restriction Fragment Length