Article
Cell lines inducibly expressing the adeno-associated virus (AAV) rep gene: requirements for productive replication of rep-negative AAV mutants.
Journal of virology - 1 Nov 1994
Hölscher C, Hörer M, Kleinschmidt J A, Zentgraf H, Bürkle A, Heilbronn R
Abstract excerpt
The adeno-associated virus (AAV) rep gene codes for a family of nonstructural proteins which are required for AAV gene regulation and DNA replication. In addition, rep has been implicated in a variety of activities outside the AAV life cycle which have been difficult to study, since attempts to a...
Topics
- DNA Replication
- DNA, Single-Stranded
- DNA, Viral
- DNA-Binding Proteins
- Dependovirus
- Gene Expression Regulation, Viral
- HeLa Cells
- Humans
- Mutation
- Viral Proteins
- Virus Replication