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Article

Cell lines inducibly expressing the adeno-associated virus (AAV) rep gene: requirements for productive replication of rep-negative AAV mutants.

Journal of virology - 1 Nov 1994

Hölscher C, Hörer M, Kleinschmidt J A, Zentgraf H, Bürkle A, Heilbronn R

Abstract excerpt

The adeno-associated virus (AAV) rep gene codes for a family of nonstructural proteins which are required for AAV gene regulation and DNA replication. In addition, rep has been implicated in a variety of activities outside the AAV life cycle which have been difficult to study, since attempts to achieve separate and constitutive expression of rep in stable cell lines have failed so far. Here we report the...

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Identifiers

PMID: 7933099
DOI: 10.1128/JVI.68.11.7169-7177.1994
PMCID: PMC237156

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