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Article

A p5 integration efficiency element mediates Rep-dependent integration into AAVS1 at chromosome 19

9 Sept 2002

Abstract excerpt

Adeno-associated virus (AAV) undergoes site-specific integration into human chromosome 19 through a deletion-substitution mechanism at the well characterized AAVS1 site. We have shown previously that a cis element within the left end of the AAV genome enhances the efficiency of Rep-mediated site-specific integration into chromosome 19 when present in inverted terminal repeat-containing recombinant AAV (rAAV)...

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PMID: 12221283
DOI: 10.1073/pnas.182430299

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A p5 integration efficiency element mediates Rep-dependent integration into AAVS1 at chromosome 19PMID 12221283Read ↗

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