Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of recombinant adeno-associated virus packaging and requirements for rep and cap gene products

1 Mar 1997

Abstract excerpt

Adeno-associated virus (AAV) is a human parvovirus currently being developed as a vector for gene therapy applications. Because the gene transfer vector commonly retains only the AAV terminal repeats, propagation of recombinant AAV (rAAV) requires that the viral replication (Rep) and capsid (Cap) proteins be supplied in trans. In an effort to optimize the production of these vectors, a panel of helper plasmids...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Parvovirus B19 Infection Studies
Share to RNA Interference and Gene Delivery
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9032320
DOI: 10.1128/jvi.71.3.1897-1905.1997

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of recombinant adeno-associated virus packaging and requirements for rep and cap gene productsPMID 9032320Read ↗

Recombinant adeno-associated virus type 2 replication and packaging is entirely supported by a herpes simplex virus type 1 amplicon expressing Rep and CapSemantic proximity Read ↗

Self-Complementary Recombinant Adeno-Associated Viral Vectors: Packaging Capacity And The Role of Rep Proteins in Vector PuritySemantic proximity Read ↗

High-titer recombinant adeno-associated virus production utilizing a recombinant herpes simplex virus type I vector expressing AAV-2 Rep and CapSemantic proximity Read ↗

Evidence for Packaging of rep-cap Sequences into Adeno-Associated Virus (AAV) Type 2 Capsids in the Absence of Inverted Terminal Repeats: a Model for Generation of rep -Positive AAV ParticlesSemantic proximity Read ↗

Improved Genome Packaging Efficiency of AAV Vectors Using Rep HybridsSemantic proximity Read ↗

Factors Influencing Recombinant Adeno-Associated Virus ProductionSemantic proximity Read ↗

Identification and elimination of replication-competent adeno-associated virus (AAV) that can arise by nonhomologous recombination during AAV vector productionSemantic proximity Read ↗

Selective Rep-Cap Gene Amplification as a Mechanism for High-Titer Recombinant AAV Production from Stable Cell LinesSemantic proximity Read ↗

Novel Tools for Production and Purification of Recombinant Adenoassociated Virus VectorsSemantic proximity Read ↗

Production of High-Titer Recombinant Adeno-Associated Virus Vectors in the Absence of Helper AdenovirusSemantic proximity Read ↗

Separate control of Rep and Cap expression using mutant and wild-type loxP sequences and improved packaging system for adeno-associated virus vector production.Semantic proximity Read ↗

Deciphering Key Adenoviral Elements in the Production of Recombinant Adeno-Associated Virus VectorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.