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Article

Impaired neurotrophin-3 signaling in a TrkAII mutant associated with hereditary polyneuropathy.

Experimental neurology - 1 Jul 2010

Flohr S, Ewers P, Fink G R, Weis J, Krüttgen A

Abstract excerpt

Mutations of the neurotrophin receptor tyrosine kinase TrkA (NTRK1) cause congenital sensory neuropathy with insensitivity to pain and anhydrosis (CIPA), also called hereditary sensory and autonomous neuropathy type IV (HSAN IV). The neuronal splice variant of TrkA, TrkAII, binds two neurotrophin ligands, nerve growth factor (NGF) and neurotrophin-3 (NT3). Several studies have demonstrated NGF signaling defects...

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Source

Identifiers

PMID: 20188729
DOI: 10.1016/j.expneurol.2010.02.009

Genes

NGF
NTRK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Impaired neurotrophin-3 signaling in a TrkAII mutant associated with hereditary polyneuropathy.PMID 20188729Read ↗

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Congenital insensitivity to pain with anhidrosis (CIPA): effect of TRKA (NTRK1) missense mutations on autophosphorylation of the receptor tyrosine kinase for nerve growth factor.Semantic proximity Read ↗

Molecular basis of congenital insensitivity to pain with anhidrosis (CIPA): mutations and polymorphisms in TRKA (NTRK1) gene encoding the receptor tyrosine kinase for nerve growth factor.Semantic proximity Read ↗

A Comprehensive Functional Analysis of NTRK1 Missense Mutations Causing Hereditary Sensory and Autonomic Neuropathy Type IV (HSAN IV).Semantic proximity Read ↗

Swedish Nerve Growth Factor Mutation (NGF <sup>R100W</sup> ) Defines a Role for TrkA and p75NTR in NociceptionSemantic proximity Read ↗

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Human TrkAR649W mutation impairs nociception, sweating and cognitive abilities: a mouse model of HSAN IV.Semantic proximity Read ↗

Taking pain out of NGF: a "painless" NGF mutant, linked to hereditary sensory autonomic neuropathy type V, with full neurotrophic activity.Semantic proximity Read ↗

The Gly571Arg mutation, associated with the autonomic and sensory disorder congenital insensitivity to pain with anhidrosis, causes the inactivation of the NTRK1/nerve growth factor receptor.Semantic proximity Read ↗

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