Article
Generation of mice with a conditional allele for the p75(NTR) neurotrophin receptor gene.
Genesis (New York, N.Y. : 2000) - 1 Nov 2011
Bogenmann Emil, Thomas Penny S, Li Qianfeng, Kim Jieun, Yang Liang-Tung, Pierchala Brian, Kaartinen Vesa
Abstract excerpt
The p75(NTR) neurotrophin receptor has been implicated in multiple biological and pathological processes. While significant advances have recently been made in understanding the physiologic role of p75(NTR) , many details and aspects remain to be determined. This is in part because the two existing knockout mouse models (Exons 3 or 4 deleted, respectively), both display features that defy definitive conclusions....
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