Rapid detection of cytomegalovirus strains resistant to ganciclovir through mutations within the gene UL97.

doi:10.1006/mcpr.1993.1072

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Article

Rapid detection of cytomegalovirus strains resistant to ganciclovir through mutations within the gene UL97.

Molecular and cellular probes - 1 Dec 1993

Alain S, Mazeron M C, Pépin J M, Morinet F, Raskine L, Sanson-Le Pors M J

Abstract excerpt

The human cytomegalovirus (HCMV) gene UL97 product was shown to play an important role in phosphorylation of ganciclovir (GCV) in HCMV-infected cells. The deletion of the 4 amino-acid sequence AACR confers resistance to a laboratory mutant. The aim of this study was to develop a rapid and simple...

Topics

Base Sequence
Bronchoalveolar Lavage Fluid
Cerebrospinal Fluid
Cytomegalovirus
Cytomegalovirus Infections
DNA Probes
Drug Resistance, Microbial
Fibroblasts
Foscarnet
Ganciclovir
Genes, Viral
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Inactivation, Metabolic

Molecular Sequence Data

Mutation

Phosphorylation

Phosphotransferases (Alcohol Group Acceptor)

Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 8145779
DOI: 10.1006/mcpr.1993.1072

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8145779-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Rapid detection of cytomegalovirus strains resistant to ganciclovir through mutations within the gene UL97.PMID 8145779Read ↗

Rapid detection by reverse hybridization of mutations in the UL97 gene of human cytomegalovirus conferring resistance to ganciclovir.Semantic proximity Read ↗

Rapid semiquantitative real-time PCR for the detection of human cytomegalovirus UL97 mutations conferring ganciclovir resistance.Semantic proximity Read ↗

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A three-nucleotide deletion in the UL97 open reading frame is responsible for the ganciclovir resistance of a human cytomegalovirus clinical isolateSemantic proximity Read ↗

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HCMV UL97 phosphotransferase gene mutations may be associated with antiviral resistance in immunocompromised patients in Belém, PA, Northern Brazil.Semantic proximity Read ↗

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