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Article

Detection of Two Drug-Resistance Mutants of the Cytomegalovirus by High-Resolution Melting Analysis.

Journal of clinical laboratory analysis - 1 Jul 2016

Chen Xiao-Fan, Li Tian-Run, Yang Hong, Shao Yong, Zhang Jie, Zhang Wei, Yu Bo, Wei Zhun, Wu Bo, Yu Lin

Abstract excerpt

BACKGROUND: Human cytomegalovirus (CMV) is an opportunistic pathogen that can be treated with ganciclovir. Mutations in the UL97 gene of CMV render the virus ganciclovir resistance. These include H520Q and C603W mutations, against which we developed a novel genotyping assay for their identification. METHODS: PCR reactions were performed to amplify fragments of the UL97 gene containing H520Q or C603W mutations....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 25968338
DOI: 10.1002/jcla.21858
PMCID: PMC6807006

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Source receipt: pubmed, retrieved 7 Sept 2026.

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