Article
The 5' non-coding region of the BCR/ABL oncogene augments its ability to stimulate the growth of immature lymphoid cells.
Oncogene - 1 Aug 1991
Gishizky M L, McLaughlin J, Pendergast A M, Witte O N
Abstract excerpt
The Philadelphia chromosome (Ph1, t9:22;34:q11) is a reciprocal translocation between chromosome 22 and chromosome 9 which results in the formation of the chimeric BCR/ABL oncogene. Alternative forms of BCR/ABL are produced by splicing different sets of exons of the BCR gene to a common set of c-...
Topics
- Animals
- B-Lymphocytes
- Base Sequence
- Cell Transformation, Neoplastic
- Fusion Proteins, bcr-abl
- Gene Expression
- Genes, abl
- Lymphoid Tissue
- Mast Cells
- Mice
- Mice, Inbred BALB C
- Molecular Sequence Data
- Open Reading Frames
- Phenotype
- Splenic Neoplasms
- T-Lymphocytes
- Transcription, Genetic
- Translocation, Genetic