Article
Heterogenic molecular basis for loss of ABL1-BCR transcription: deletions in der(9)t(9;22) and variants of standard t(9;22) in BCR-ABL1-positive chronic myeloid leukemia.
Genes, chromosomes & cancer - 1 Jun 2002
Loncarevic Ivan F, Römer Jennifer, Starke Heike, Heller Anita, Bleck Cordula, Ziegler Monika, Fiedler Wolfgang, Liehr Thomas, Clement Joachim H, Claussen Uwe
Abstract excerpt
The objective of this study was to characterize the ABL1-BCR fusion gene in 76 BCR-ABL1-positive chronic myeloid leukemia (CML) patients regarding expression as well as genomic status, to assess the frequency of ABL1-BCR gene deletion in these patients, which has been reported to be an adverse prognostic factor in Philadelphia chromosome-positive CML. Patients were analyzed for ABL1-BCR 1b-b3 and/or 1b-b4...
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