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Article

Genomic Mechanisms of p210BCR-ABL Signaling

1 Aug 2004

Abstract excerpt

Chronic myelogenous leukemia (CML) results from a t(9,22) translocation, producing the p210(BCR-ABL) oncoprotein, a tyrosine kinase that causes transformation and chemotherapy resistance. To further understand mechanisms mediating chemotherapy resistance, we identified 556 differentially regulated genes in HL-60 cells stably expressing p210(BCR-ABL) versus those expressing an empty vector using cDNA macro- and...

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PMID: 15155749
DOI: 10.1074/jbc.m401851200

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Genomic Mechanisms of p210BCR-ABL SignalingPMID 15155749Read ↗

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