Article
The t(2;3)(q21;q27) translocation in non-Hodgkin's lymphoma displays BCL6 mutations in the 5' regulatory region and chromosomal breakpoints distant from the gene.
Oncogene - 1 Oct 1998
Chen W, Butler M, Rao P H, Chaganti S R, Louie D C, Dalla-Favera R, Chaganti R S
Abstract excerpt
The BCL6 gene, mapped at the chromosomal band 3q27, encodes a POZ/Zinc finger transcription repressor protein. It is frequently activated in Non-Hodgkin's lymphomas (NHL) by translocations with breakpoints clustering in the 5' major breakpoint region (MBR) as well as by mutations in the same regi...
Topics
- Alleles
- Blotting, Southern
- Chromosome Breakage
- Chromosomes, Human, Pair 2
- Chromosomes, Human, Pair 3
- DNA-Binding Proteins
- Gene Rearrangement
- Humans
- Lymphoma, Non-Hodgkin
- Male
- Middle Aged
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational