Article
Molecular analysis of mutations induced at the hisD3052 allele of Salmonella by single chemicals and complex mixtures.
Environmental health perspectives - 1 Oct 1993
DeMarini D M, Bell D A, Levine J G, Shelton M L, Abu-Shakra A
Abstract excerpt
More single chemicals and complex environmental mixtures have been evaluated for mutagenicity at the hisD3052 allele of Salmonella, primarily in strain TA98, than in any other mutation assay. The development of colony probe hybridization procedures and the application of the polymerase chain reaction and direct DNA sequencing has permitted rapid molecular access to this allele. We discuss these techniques and the...
Topics
- Alleles
- Environmental Pollutants
- Mutagens
- Mutation
- Salmonella