Article
Complex frameshift mutations mediated by plasmid pKM101: mutational mechanisms deduced from 4-aminobiphenyl-induced mutation spectra in Salmonella.
Genetics - 1 Mar 1994
Levine J G, Schaaper R M, DeMarini D M
Abstract excerpt
We used colony probe hybridization and polymerase chain reaction/DNA sequence analysis to determine the mutations in approximately 2,400 4-aminobiphenyl (4-AB) +S9-induced revertants of the -1 frameshift allele hisD3052 and of the base-substitution allele hisG46 of Salmonella typhimurium. Most of...
Topics
- Alleles
- Aminobiphenyl Compounds
- Base Sequence
- DNA, Bacterial
- Dose-Response Relationship, Drug
- Frameshift Mutation
- Models, Genetic
- Molecular Sequence Data
- Mutagenesis
- Plasmids
- Salmonella typhimurium