Genome resequencing analysis of Salmonella typhimurium LT-2 strains TA98 and TA100 for the establishment of a next-generation sequencing-based mutagenicity assay.

Abstract excerpt

Next-generation sequencing (NGS) is a potentially useful technology to achieve a more precise evaluation of chemical mutagenicity. To establish NGS-based mutagenicity assays, which enable the direct detection of chemically induced mutations in a whole genome manner, the selection of appropriate biological resources and their precise genome sequences are essential. Here, we performed genome re-sequencing analyses...

Topics

• DNA Damage
• DNA, Bacterial
• Genome, Bacterial
• High-Throughput Nucleotide Sequencing
• Mutagenicity Tests
• Mutation