Article
Absence of metalloprotease GP63 alters the protein content of Leishmania exosomes.
PloS one - 1 Jan 2014
Hassani Kasra, Shio Marina Tiemi, Martel Caroline, Faubert Denis, Olivier Martin
Abstract excerpt
Protozoan parasites of Leishmania genus are able to successfully infect their host macrophage due to multiple virulence strategies that result in its deactivation. Recent studies suggest Leishmania GP63 to be a critical virulence factor in modulation of many macrophage molecules, including protein tyrosine phosphatases (PTPs) and transcription factors (TFs). Additionally, we and others recently reported that...
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