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Article

Isolation, characterization and epistasis of fluoride-resistant mutants of Caenorhabditis elegans.

Genetics - 1 Jan 1994

Katsura I, Kondo K, Amano T, Ishihara T, Kawakami M

Abstract excerpt

We have isolated 13 fluoride-resistant mutants of the nematode Caenorhabditis elegans. All the mutations are recessive and mapped to five genes. Mutants in three of the genes (class 1 genes: flr-1 X, flr-3 IV, and flr-4 X) are resistant to 400 micrograms/ml NaF. Furthermore, they grow twice as slowly as and have smaller brood size than wild-type worms even in the absence of fluoride ion. In contrast, mutants in...

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Identifiers

PMID: 8138152
DOI: 10.1093/genetics/136.1.145
PMCID: PMC1205766

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