Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Positive selection of Caenorhabditis elegans mutants with increased stress resistance and longevity.

Genetics - 1 Jan 2003

Muñoz Manuel J, Riddle Donald L

Abstract excerpt

We developed selective conditions for long-lived mutants of the nematode Caenorhabditis elegans by subjecting the first larval stage (L1) to thermal stress at 30 degrees for 7 days. The surviving larvae developed to fertile adults after the temperature was shifted to 15 degrees. A total of one million F(2) progeny and a half million F(3) progeny of ethyl-methanesulfonate-mutagenized animals were treated in three...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins
Share to Forkhead Transcription Factors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hot Temperature

Share to Longevity

Share to Selection, Genetic

Share to Starvation

Share to Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 12586705
DOI: 10.1093/genetics/163.1.171
PMCID: PMC1462431

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Positive selection of Caenorhabditis elegans mutants with increased stress resistance and longevity.PMID 12586705Read ↗

Longevity genes in the nematode Caenorhabditis elegans also mediate increased resistance to stress and prevent disease.Semantic proximity Read ↗

Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans.Semantic proximity Read ↗

Genes that regulate both development and longevity in Caenorhabditis elegans.Semantic proximity Read ↗

Genetic analysis of the roles of daf-28 and age-1 in regulating Caenorhabditis elegans dauer formation.Semantic proximity Read ↗

Using stress resistance to isolate novel longevity mutations in Caenorhabditis elegans.Semantic proximity Read ↗

Thermotolerance of a long-lived mutant of Caenorhabditis elegans.Semantic proximity Read ↗

Direct isolation of longevity mutants in the nematode Caenorhabditis elegans.Semantic proximity Read ↗

Gerontogenes mediate health and longevity in nematodes through increasing resistance to environmental toxins and stressors.Semantic proximity Read ↗

A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results.Semantic proximity Read ↗

The nuclear hormone receptor DAF-12 has opposing effects on Caenorhabditis elegans lifespan and regulates genes repressed in multiple long-lived worms.Semantic proximity Read ↗

A C. elegans mutant that lives twice as long as wild type.Semantic proximity Read ↗

Characterization of a life-extending mutation in age-2, a new aging gene in Caenorhabditis elegans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.