Disruption of a neuropeptide gene, flp-1, causes multiple behavioral defects in Caenorhabditis elegans.

doi:10.1126/science.281.5383.1686

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Article

Disruption of a neuropeptide gene, flp-1, causes multiple behavioral defects in Caenorhabditis elegans.

Science (New York, N.Y.) - 11 Sept 1998

Nelson L S, Rosoff M L, Li C

Abstract excerpt

Neuropeptides serve as important signaling molecules in the nervous system. The FMRFamide (Phe-Met-Arg-Phe-amide)-related neuropeptide gene family in the nematode Caenorhabditis elegans is composed of at least 18 genes that may encode 53 distinct FMRFamide-related peptides. Disruption of one of t...

Topics

Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
FMRFamide
GTP-Binding Proteins
Genes, Helminth
Helminth Proteins
Motor Activity
Movement
Mutation
Neuropeptides
Osmolar Concentration

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Polymerase Chain Reaction

Sequence Deletion

Serotonin

Signal Transduction

Transgenes

Source

Open in PubMed

Identifiers

PMID: 9733518
DOI: 10.1126/science.281.5383.1686

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9733518-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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