Article
Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions.
PLoS biology - 1 Oct 2003
Simmer Femke, Moorman Celine, van der Linden Alexander M, Kuijk Ewart, van den Berghe Peter V E, Kamath Ravi S, Fraser Andrew G, Ahringer Julie, Plasterk Ronald H A
Abstract excerpt
RNA-mediated interference (RNAi) is a method to inhibit gene function by introduction of double-stranded RNA (dsRNA). Recently, an RNAi library was constructed that consists of bacterial clones expressing dsRNA, corresponding to nearly 90% of the 19,427 predicted genes of C. elegans. Feeding of this RNAi library to the standard wild-type laboratory strain Bristol N2 detected phenotypes for approximately 10% of...
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