Article
Maturation of neonatal human CD4 T cells: III. Role of B7 co-stimulation at priming.
International immunology - 1 Dec 1995
Yang L P, Demeure C E, Byun D G, Vezzio N, Delespesse G
Abstract excerpt
We previously reported that human naive CD4 T cells differentiate into effector cells producing type 1 (IL-2, IFN-gamma) and type 2 (IL-4, IL-5, IL-10) cytokines after priming with anti-CD3 mAb presented on irradiated CD32-transfected mouse L fibroblasts, in the absence of exogenous cytokine. Her...
Topics
- Animals
- Antibodies, Monoclonal
- B7-1 Antigen
- CD28 Antigens
- CD3 Complex
- CD4-Positive T-Lymphocytes
- Cell Differentiation
- Cytokines
- Humans
- In Vitro Techniques
- Infant, Newborn
- Interleukin-4
- L Cells
- Lymphocyte Activation
- Mice
- Phenotype
- Receptors, IgG
- Signal Transduction