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Article

Alloreactivity of ex vivo-expanded T cells is correlated with expansion and CD4/CD8 ratio.

Cytotherapy - 1 Jan 2008

Mercier-Letondal P, Montcuquet N, Sauce D, Certoux J-M, Jeanningros S, Ferrand C, Bonyhadi M, Tiberghien P, Robinet E

Abstract excerpt

Background We have demonstrated previously that retroviral-mediated transfer of a suicide gene into bone marrow (BM) donor T cells allows an efficient control of graft-versus-host disease (GvHD) after allogeneic BM transplantation. However, the 12 days of ex vivo culture required for the production of gene-modified cells (GMC), including soluble CD3 monoclonal antibody (MAb)-mediated activation and expansion with...

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PMID: 18418773
DOI: 10.1080/14653240801927032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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