A biological method for examining the effect of codon changes in a conserved region of DNA polymerase.

Article

A biological method for examining the effect of codon changes in a conserved region of DNA polymerase.

BioTechniques - 1 Jan 1994

DeFilippes F M

Abstract excerpt

The vaccinia virus genome encodes a DNA polymerase that is similar to other DNA polymerases. A mutation in the polymerase gene at a site that is adjacent to conserved residues allows viral replication in the presence of aphidicolin. Since wild-type virus is converted to aphidicolin-resistance by...

Topics

Amino Acid Sequence
Aphidicolin
Base Sequence
Codon
Conserved Sequence
DNA-Directed DNA Polymerase
Molecular Sequence Data
Mutation
Structure-Activity Relationship
Vaccinia virus

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