Failla Memorial Lecture. The prevalence of multilocus lesions in radiation-induced mutants.

Article

Failla Memorial Lecture. The prevalence of multilocus lesions in radiation-induced mutants.

Radiation research - 1 Feb 1994

Evans H H

Abstract excerpt

In L5178Y mouse lymphoblasts, ionizing radiation-induced mutant frequencies were dramatically higher when the genetic marker analyzed was heterozygous (tk+/tk-) than when hemizygous (tk+/tk0 or hprt+/hprt0). In contrast, base-change mutagens induced similar mutant frequencies at heterozygous and...

Topics

Animals
Cell Line
DNA Damage
DNA Repair
History, 20th Century
Hypoxanthine Phosphoribosyltransferase
Mice
Mutation
Radiation Effects
Radiology
Thymidine Kinase
Topoisomerase II Inhibitors
United States

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