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Failla Memorial Lecture. The prevalence of multilocus lesions in radiation-induced mutants.

Radiation research - 1 Feb 1994

Evans H H

Abstract excerpt

In L5178Y mouse lymphoblasts, ionizing radiation-induced mutant frequencies were dramatically higher when the genetic marker analyzed was heterozygous (tk+/tk-) than when hemizygous (tk+/tk0 or hprt+/hprt0). In contrast, base-change mutagens induced similar mutant frequencies at heterozygous and hemizygous loci. These results indicate that the majority of radiation-induced mutants harbor multilocus lesions, and...

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PMID: 8134537

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