Article
The effect of dose rate on X-radiation-induced mutant frequency and the nature of DNA lesions in mouse lymphoma L5178Y cells.
Radiation research - 1 Jun 1990
Evans H H, Nielsen M, Mencl J, Horng M F, Ricanati M
Abstract excerpt
The induction of mutants at the heterozygous tk locus by X radiation was found to be dose-rate dependent in L5178Y-R16 (LY-R16) cells, but very little dose-rate dependence was observed in the case of strain L5178Y-S1 (LY-S1), which is deficient in the repair of DNA double-strand breaks. Induction...
Topics
- Animals
- DNA Damage
- DNA, Neoplasm
- Dose-Response Relationship, Radiation
- In Vitro Techniques
- Leukemia L5178
- Mice
- Mutation
- Radiation Genetics
- Tumor Cells, Cultured