Predominantly tumor-limited expression of a mutant allele in a Japanese family carrying a germline p53 mutation.

Article

Predominantly tumor-limited expression of a mutant allele in a Japanese family carrying a germline p53 mutation.

Oncogene - 1 Apr 1994

Horio Y, Suzuki H, Ueda R, Koshikawa T, Sugiura T, Ariyoshi Y, Shimokata K, Takahashi T, Takahashi T

Abstract excerpt

Germline mutations of p53 have been implicated as a cause of cancer susceptibility in the Li-Fraumeni syndrome. Since inactivation of p53 has been suggested to play an important causative role in lung cancer, the present study of the prevalence of germline mutations in 148 patients with this neop...

Topics

Adult
Alleles
Female
Genes, p53
Germ-Line Mutation
Humans
Immunohistochemistry
Japan
Lung Neoplasms
Pedigree
Polymerase Chain Reaction

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