Article
Expression of p53 mutant nuclear phosphoprotein in oral carcinoma and potentially malignant oral lesions.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology - 1 Oct 1992
Warnakulasuriya K A, Johnson N W
Abstract excerpt
An immunohistochemical study of primary oral squamous cell carcinomas (n = 37) with a monoclonal antibody (PAb 1801) specific to p53 antioncogene product demonstrated nuclear overexpression of the mutant protein in 35% of cases. Those positive included carcinomas without deep invasion suggesting...
Topics
- Carcinoma
- Carcinoma in Situ
- Carcinoma, Squamous Cell
- Cell Nucleus
- Female
- Gene Expression
- Humans
- Keratosis
- Leukoplakia, Oral
- Male
- Middle Aged
- Mouth Mucosa
- Mouth Neoplasms
- Mutation
- Precancerous Conditions
- Tumor Suppressor Protein p53