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Article

Prenatal diagnosis from maternal blood: simultaneous immunophenotyping and FISH of fetal nucleated erythrocytes isolated by negative magnetic cell sorting.

Journal of medical genetics - 1 Dec 1993

Zheng Y L, Carter N P, Price C M, Colman S M, Milton P J, Hackett G A, Greaves M F, Ferguson-Smith M A

Abstract excerpt

Fetal nucleated cells in the maternal circulation constitute a potential source of cells for the non-invasive prenatal diagnosis of fetal genetic abnormalities. We have investigated the use of the Magnetic Activated Cell Sorter (MACS) for enriching fetal nucleated erythrocytes. Mouse monoclonal antibodies specific for CD45 and CD32 were used to deplete leucocytes from maternal blood using MACS sorting, thus...

Topics

Cell Separation
Erythrocytes
Female
Fetal Blood
Genetic Diseases, Inborn
Humans
Immunophenotyping
In Situ Hybridization, Fluorescence
Magnetics
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pregnancy

Prenatal Diagnosis

Source

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Identifiers

PMID: 8133505
DOI: 10.1136/jmg.30.12.1051
PMCID: PMC1016647

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8133505-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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