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Detection of Fetal Trisomies 21 and 18 From Maternal Blood Using Triple Gradient and Magnetic Cell Sorting

10 Sept 1993

Abstract excerpt

PROBLEM: The need for an inexpensive and reproducible technique for noninvasive prenatal diagnosis by fetal cell isolation from maternal blood. METHOD: For enrichment of fetal cells we used a combination of triple density gradient and magnetic sorting (MACS) of (anti-CD71) transferrin receptor antibody labeled cells followed by fluorescence in situ hybridization (FISH) with chromosome-specific DNA probes for...

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Share to Fetal and Pediatric Neurological Disorders
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Share to Prenatal Screening and Diagnostics

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PMID: 8311928
DOI: 10.1111/j.1600-0897.1993.tb00620.x

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Detection of Fetal Trisomies 21 and 18 From Maternal Blood Using Triple Gradient and Magnetic Cell SortingPMID 8311928Read ↗

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