Article
Interactions of amino terminal domains of Shaker K channels with a pore blocking site studied with synthetic peptides.
The Journal of general physiology - 1 Dec 1993
Murrell-Lagnado R D, Aldrich R W
Abstract excerpt
Synthetic peptides of the five alternative NH2-terminal sequences of Shaker when applied to the cytoplasmic side of ShB channels that have an NH2-terminal deletion (ShB delta 6-46) block the channel with potencies correlated with the rate of inactivation in the corresponding variant. These peptid...
Topics
- Amino Acid Sequence
- Animals
- DNA Probes
- DNA, Complementary
- Electrophysiology
- Kinetics
- Molecular Sequence Data
- Mutation
- Peptides
- Potassium Channels
- Protein Conformation
- Shaker Superfamily of Potassium Channels
- Tetraethylammonium Compounds
- Xenopus laevis