Article
N-type inactivation of the potassium channel KcsA by the Shaker B "ball" peptide: mapping the inactivating peptide-binding epitope.
The Journal of biological chemistry - 27 Jun 2008
Molina M Luisa, Barrera Francisco N, Encinar José A, Renart M Lourdes, Fernández Asia M, Poveda José A, Santoro Jorge, Bruix Marta, Gavilanes Francisco, Fernández-Ballester Gregorio, Neira José L, González-Ros José M
Abstract excerpt
The effects of the inactivating peptide from the eukaryotic Shaker BK(+) channel (the ShB peptide) on the prokaryotic KcsA channel have been studied using patch clamp methods. The data show that the peptide induces rapid, N-type inactivation in KcsA through a process that includes functional uncoupling of channel gating. We have also employed saturation transfer difference (STD) NMR methods to map the molecular...
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