Article
Probing the channel-bound shaker B inactivating peptide by stereoisomeric substitution at a strategic tyrosine residue.
Biochemistry - 29 Jul 2003
Encinar J A, Fernández A M, Poveda J A, Molina M L, Albar J P, Gavilanes F, Gonzalez-Ros J M
Abstract excerpt
A synthetic peptide patterned after the sequence of the inactivating ball domain of the Shaker B K(+) channel, the ShB peptide, fully restores fast inactivation in the deletion Shaker BDelta6-46 K(+) channel, which lacks the constitutive ball domains. On the contrary, a similar peptide in which t...
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