Article
Familial adult onset hyperinsulinism due to an activating glucokinase mutation: implications for pharmacological glucokinase activation.
Clinical endocrinology - 1 Dec 2014
Challis Benjamin G, Harris Julie, Sleigh Alison, Isaac Iona, Orme Steve M, Seevaratnam Nandini, Dhatariya Ketan, Simpson Helen L, Semple Robert K
Abstract excerpt
CONTEXT: Glucokinase (GCK) phosphorylates and thereby "traps" glucose in cells, thus serving as a gatekeeper for cellular glucose metabolism, particularly in hepatocytes and pancreatic beta cells. In humans, activating GCK mutations cause familial hyperinsulinaemic hypoglycaemia (GCK-HH), leading to keen interest in the potential of small-molecule glucokinase activators (GKAs) as treatments for diabetes mellitus....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.