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Article

Regulation of pancreatic beta-cell glucokinase: from basics to therapeutics.

Diabetes - 1 Dec 2002

Matschinsky Franz M

Abstract excerpt

Glucokinase (GK) serves as glucose sensor in pancreatic beta-cells and in other glucose sensor cells in the body. Biochemical genetic studies have characterized many activating and inactivating GK mutants that have been discovered in patients with hyperinsulinemic hypoglycemia or diabetes, all inherited as autosomal dominant traits. Mathematical modeling of the kinetic data of recombinant human wild-type and...

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PMID: 12475782
DOI: 10.2337/diabetes.51.2007.s394

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Regulation of pancreatic beta-cell glucokinase: from basics to therapeutics.PMID 12475782Read ↗

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