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Article

Genomic instability in early systemic sclerosis

1 Jul 2022

Abstract excerpt

OBJECTIVES: Systemic sclerosis (SSc) is associated with secondary malignancies. Previous studies have suggested that mutated cancer proteins, such as RNA polymerase III, are autoantigens promoting an inflammatory response in SSc. However, it has never been previously investigated whether non-neoplastic tissue in SSc harbors mutations which may play a role in SSc pathogenesis. METHODS: Skin biopsies were obtained...

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PMID: 35803104
DOI: 10.1016/j.jaut.2022.102847

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