Article
Clonal haematopoiesis is increased in early onset in systemic sclerosis.
Rheumatology (Oxford, England) - 1 Nov 2020
Ricard Laure, Hirsch Pierre, Largeaud Laëtitia, Deswarte Caroline, Jachiet Vincent, Mohty Mohamad, Rivière Sébastien, Malard Florent, Tenon Maxime, de Vassoigne Frédéric, Fain Olivier, Gaugler Béatrice, Rossignol Julien, Delhommeau François, Mekinian Arsène
Abstract excerpt
OBJECTIVES: SSc is an autoimmune disease characterized by fibrosis, microangiopathy and immune dysfunctions including dysregulation of proinflammatory cytokines. Clonal haematopoiesis of indeterminate potential (CHIP) is defined by the acquisition of somatic mutations in haematopoietic stem cells leading to detectable clones in the blood. Recent data have shown a higher risk of cardiovascular disease in patients...
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